Gastric cancer in patients aged younger and older than 50 years: characteristics of gastric cancer and survival analysis
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Published:2022-05-05
Issue:2
Volume:21
Page:24-37
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ISSN:2312-3168
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Container-title:Siberian journal of oncology
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language:
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Short-container-title:Sib. onkol. ž.
Author:
Kovalenko N. V.1ORCID, Zhavoronkova V. V.1ORCID, Ivanov A. I.1ORCID, Postolov M. P.1ORCID, Tolstopyatov S. E.1ORCID, Dzhafarov D. D.2ORCID, Pavlovskaya P. M.3ORCID, Suvorov V. A.1ORCID
Affiliation:
1. Volgograd Regional Clinical Cancer Center;
Volgograd State Medical University 2. Volgograd Regional Clinical Cancer Center 3. Volgograd State Medical University
Abstract
Objective. To study clinical and pathological characteristics of gastric cancer in patients aged younger and older than 50 years, who received anticancer treatment including surgery, as well as to identify prognostic factors for overall survival of these patients.Material and methods. A retrospective study of surgical treatment outcomes was conducted in 350 gastric cancer patients, who were divided into 2 groups. The study group included 34 (9.71 %) patients aged 50 years and younger and the control group consisted of 316 (90.29 %) patients aged 51 years and older.Results. The analysis of treatment outcomes and survival rates was carried out. The diffuse-type gastric cancer was more frequently diagnosed in younger than in older patients (p<0.001), and asymptomatic disease often present in younger patients (p<0.001). There were no differences in the extent of surgery between the groups (p=0.613). The overall survival rate was lower in the control group than in the study group (p=0.002). The multivariate analysis revealed that a worse prognosis was observed in patients of the control group (hr=12.71), with regional lymph node metastases (hr=2.64), distant metastases (hr=1.83), iii/iv stage of the disease (hr=2.01), lymphovascular (hr=3.15) and perineural invasion (hr=2.46), as well as with postoperative complications (hr=2.12). Adjuvant chemotherapy improved the disease prognosis (hr=0.35).Conclusion. Specific clinical and pathological features predicted survival of gastric cancer patients aged younger and older 50 years.
Publisher
Tomsk Cancer Research Institute
Subject
Cancer Research,Oncology
Reference23 articles.
1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6): 394–424. doi: 10.3322/caac.21492. 2. Kaprin A.D., Starinskii V.V., Shakhzadova A.O. Malignant neoplasms in Russia in 2019 (morbidity and mortality). Moscow, 2020. 252 p. (in Russian). 3. Abdullaev A.G., Allahverdiev A.K., Besova N.S., Byahov M.Y., Gorbunova V.A., Davidov M.I., Davidov M.M., Ibraev M.A., Karseladze A.I., Kyvshinov Y.P., Malihova O.A., Nered S.N., Stilidi I.S., Tryakin A.A. Clinical Guidelines «Gastric Cancer». 2018. 1–34. (in Russian). 4. Kono Y., Kanzaki H., Iwamuro M., Kawano S., Kawahara Y., Okada H. Reality of Gastric Cancer in Young Patients: The Importance and Difficulty of the Early Diagnosis, Prevention and Treatment. Acta Med Okayama. 2020; 74(6): 461–6. doi: 10.18926/AMO/61204. 5. Van Der Post R.S., Vogelaar I.P., Manders P., Van Der Kolk L.E., Cats A., Van Hest L.P., Sijmons R., Aalfs C.M., Ausems M.G.E.M., Gómez Gar-cía E.B., Wagner A., Hes F.J., Arts N., Mensenkamp A.R., Van Krieken J.H., Hoogerbrugge N., Ligtenberg M.J.L. Accuracy of Hereditary Diffuse Gastric Cancer Testing Criteria and Outcomes in Patients With a Germline Mutation in CDH1. Gastroenterology. 2015. https://doi.org/10.1053/j.gastro.2015.06.003.
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