Non-invasive diagnosis of upper airway malignancies based on the analysis of markers in exhaled air-Reference-Cited by-同舟云学术

Non-invasive diagnosis of upper airway malignancies based on the analysis of markers in exhaled air

Published:2023-12-29 Issue:6 Volume:22 Page:7-15
ISSN:2312-3168
Container-title:Siberian journal of oncology
language:
Short-container-title:Sib. onkol. ž.

Author:

Kulbakin D. E.¹^ORCID,Choynzonov E. L.¹^ORCID,Fedorova I. K.¹^ORCID,Obkhodskaya E. V.²^ORCID,Obkhodskiy A. V.³^ORCID,Rodionov E. O.⁴^ORCID,Sachkov V. I.²^ORCID,Chernov V. I.¹^ORCID

Affiliation:

1. Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

2. National Research Tomsk State University

3. National Research Tomsk Polytechnic University

4. Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University of the Ministry of Health of Russia

Abstract

The purpose of the study was to evaluate diagnostic capabilities of the gas analysis sensor device used for the study of exhaled gas samples obtained from patients with oropharyngeal and laryngeal cancers.Material and Methods. Exhaled gas samples from 31 oropharyngeal and laryngeal cancer patients and 31 healthy volunteers were studied using a diagnostic device based on the detection of volatile compounds in inhaled air using semiconductor gas sensors with subsequent neural network analysis.Results. Based on the signals from gas sensors, the neural network classified and identified patients with malignant neoplasms. The sensitivity and specificity of the method were 67.74% and 87.1%, respectively.Conclusion. The gas analysis sensor device and the method for detecting oropharyngeal and laryngeal tumors using the exhaled gas analysis are an accessible and cheap diagnostic tools, and are promising for screening the population in order to select individuals for a comprehensive examination (endoscopic, radiological and morphological) in identifying suspicion of cancer.

Publisher

Tomsk Cancer Research Institute

Reference12 articles.

1. Cancer care for the population of Russia in 2021. Ed. by A.D. Kaprin, V.V. Starinsky, A.O. Shakhzadova. Moscow, 2022. 239 p. (in Russian).

2. Panferova O.I., Nikolenko V.N., Kochurova E.V., Kudasova E.O. Etiology, pathogenesis, basic principles of treatment of squamous cell carcinoma of the oral mucosa. Head and neck. Russian Journal. 2022; 10(2): 69–77. (in Russian). doi: 10.25792/HN.2022.10.2.69-77.

3. The National Comprehensive Cancer Network [Internet]. Clinical Practice Guidelines in Oncology. [cited 2023 May 15]. URL: https://www.nccn.org/professionals/physician_gls/default.aspx.

4. Harris A., Lyu L., Wasserman-Winko T., George S., Johnson J.T., Nilsen M.L. Neck Disability and Swallowing Function in Posttreatment Head and Neck Cancer Patients. Otolaryngol Head Neck Surg. 2020; 163(4): 763–70. doi: 10.1177/0194599820923630.

5. Krilaviciute A., Stock C., Leja M., Brenner H. Potential of noninvasive breath tests for preselecting individuals for invasive gastric cancer screening endoscopy. J. Breath Res. 2018; 12. doi: 10.1088/1752-7163/aab5be.