1. From the Diabetes, Endocrinology, and Metabolism Centre, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre (L.L., W.M., N.K., M.C., H.T.), the Division of Diabetes, Endocrinology, and Gastroenterology, Faculty of Biology, Medicine, and Health (L.L., H.T.), and the Centre for Biostatistics (C.J.S., V.P.T.), the Manchester Centre for Health Economics (R.A.E., G.G.), and the Manchester Clinical Trials Unit (C.J.S., M.B.), Division of Population...