1. From the Interdepartmental Division of Critical Care, University of Toronto (L.M., L.J.B.), the Critical Care Department Sinai Health System (L.M.), and Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Unity Health Toronto (L.J.B.) — all in Toronto; and the Intensive Care Department, Hospital Universitari de La Santa Creu I Sant Pau, Barcelona (J.M.).