Response and Resistance to Menin Inhibitor in UBTF –Tandem Duplication AML
Author:
Affiliation:
1. Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
2. Royal Melbourne Hospital, Melbourne, VIC, Australia
Funder
Wilson Centre for Blood Cancer Genomics
National Health and Medical Research Council
Snowdome Foundation
Publisher
Massachusetts Medical Society
Link
http://www.nejm.org/doi/pdf/10.1056/NEJMc2404110
Reference5 articles.
1. Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
2. The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia
3. Acute myeloid leukemias with UBTF tandem duplications are sensitive to Menin inhibitors
4. Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML
5. MEN1 mutations mediate clinical resistance to menin inhibition
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