1. From the Pediatric Therapeutics and Regulatory Science Initiative and the Computational Health Informatics Program, Boston Children’s Hospital, and the Department of Pediatrics, Harvard Medical School (F.T.B.), and the Program on Regulation, Therapeutics, and Law, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School (A.S.K.) — all in Boston.