Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19

Author:

Cao Bin1,Wang Yeming1,Lu Hongzhou1,Huang Chaolin1,Yang Yumei1,Shang Lianhan1,Chen Zhu1,Jiang Rongmeng1,Liu Yihe1,Lin Ling1,Peng Ping1,Wang Fuxiang1,Gong Fengyun1,Hu Honglin1,Cheng Cong1,Yao Xiangyang1,Ye Xianwei1,Zhou Hourong1,Shen Yinzhong1ORCID,Liu Chenfan1,Wang Chunying1,Yi Zhennan1,Hu Bijie1,Xu Jiuyang1ORCID,Gu Xiaoying1,Shen Jingshan1,Xu Yechun1,Zhang Leike1,Fan Jia1,Tang Renhong1,Wang Chen1

Affiliation:

1. From the Departments of Pulmonary and Critical Care Medicine (B.C., Y.W., L.S., J.X., Chen Wang) and Clinical Research and Data Management (X.G.), Institute of Respiratory Medicine in the Chinese Academy of Medical Sciences, National Clinical Research Center for Respiratory Diseases, National Center for Respiratory Medicine, China–Japan Friendship Hospital, Changping Laboratory (B.C., Chen Wang), the Department of Medicine, Non-oncology, Jiangsu Simcere Pharmaceutical (Y.Y.), Clinical and Research...

Publisher

Massachusetts Medical Society

Reference22 articles.

1. Johns Hopkins Coronavirus Resource Center. COVID-19 dashboard (https://coronavirus.jhu.edu/map.html).

2. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

3. Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution.;Cao Y;Nature,2023

4. Coronavirus (COVID-19) update: FDA authorizes first oral antiviral for treatment of COVID-19. News release of the Food and Drug Administration Silver Spring MD December 22 2021 (https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-oral-antiviral-treatment-covid-19).

5. A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-Like Protease Inhibitor, in Japanese Patients with Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a Part

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