Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia
Author:
Affiliation:
1. From Great Ormond Street Hospital for Children NHS Trust (R.C., G.O., T.B., J.C., S.A., R.T., K.G., D.O., A.V., W.Q.) and the UCL Great Ormond Street Institute of Child Health (C.G., F.S., H.Z., A.E., S.A.G., R.P., A.K., W.Q.) — both in London.
Funder
Medical Research Council
Wellcome
National Institute for Health and Care Research
Publisher
Massachusetts Medical Society
Subject
General Medicine
Link
http://www.nejm.org/doi/pdf/10.1056/NEJMoa2300709
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1. Genome-edited allogeneic donor “universal” chimeric antigen receptor T cells
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4. CRISPR-Mediated Base Editing Enables Efficient Disruption of Eukaryotic Genes through Induction of STOP Codons
5. Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS Prodigy
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