Studying the proliferation activity of the plant ?aper (Capparis spinosa L.)

Abstract

The article presents information on the methods and results of studying the influence of extracts prepared from various organs of the caper plant (Capparis spinosa L.), which in the Samarkand region exhibits the absence of proliferative activity of monocyte macrophages and mouse RAW 264.7. There are many scientific and research works devoted to the study of the medicinal properties of Capparis spinose L. cappers growing in Uzbekistan, as well as many works dedicated to identifying the molecular mechanisms of the immunomodulatory properties of the plant, which have not yet been studied. In medicine, consuming ripe fruits of C. spinosa L. has long been known to treat various diseases' inflammatory processes, including stomach inflammation and intestinal bleeding processes of haemorrhoids. The experiments show that concentrations of plant extracts at a concentration of 25.5 ?l have a destructive effect on all samples. A concentration of 1 ?l reduces the proliferative activity of cells of all plant extracts, except for seed extract; as a result, when exposed to 1 ?l of seed extraction, the population level was the highest. In cells stimulated with LPS, the level of proliferation was high at a concentration of 0.5 ?l of extracts of flowers, fruits and roots. Cytotoxicity was observed in extratax leaves, which may explain the antibacterial activity.