Association of pre-diabetes with increased obesity and depression in older male and female: A secondary analysis of the Korea National Health and Nutrition Examination Survey 2020

Abstract

Purpose: This study aimed to investigate the association among pre-diabetes, increased obesity, and depression in Korean older men and women. Methods: Data of 1,005 participants (≥65 years) were extracted from the Korea National Health and Nutrition Examination Survey (KNHANES) VIII-2, 2020. A complex sampling design was adopted to reflect stratification, clustering, and weights. Data were analyzed using t-test, Rao-Scott chi-square test, and simple and multiple logistic regression. In predicting the risk factors for pre-diabetes, after adjusting, multiple logistic regression analysis was performed to confirm the relative contribution of each predictor variable. Results: Body mass index, waist circumference (WC), and incidence of depression were higher in the pre-diabetes group than in the normal group. According to the simple logistic regression analyses, in men, the odds ratio (OR) of pre-diabetes increased by 1.73, 2.25, and 2.53 for obesity (25.0~29.9 kg/m2), high obesity (≥30.0 kg/m2), and abdominal obesity (AO) (WC≥90 cm), respectively. In women, the OR of pre-diabetes increased by 2.15, 2.30, and 3.12 for high obesity, AO (WC≥85 cm) and depression diagnosis, respectively. In the adjusted analysis, in men, the adjusted odds ratio (AOR) of pre-diabetes increased by 2.73 and 1.97 for high obesity and AO (WC≥90 cm), respectively. In women, the AOR for pre-diabetes increased by 3.74 and 2.19 for depression diagnosis and no treatment for depression, respectively. Conclusion: This study provides evidence that interventions for obesity and depression should be included differently in pre-diabetes management programs for older men and women.