The influence of small amount of substances present in tissue on immunosuppressive drug optical spectrum

Abstract

In this paper, we describe how commonly present in tissue substances - sodium chloride and glucose - affect the optical spectrum of an immunosuppressive drug (Cyclaid® by Apotex). Prepared samples were investigated using the spectrophotometer in the spectrum range from 250 nm to 1100 nm. The maximum wavelength shift calculated on the basis of measurement results is not bigger than the measurement wavelength step. So, it can be concluded, that the small amount of sodium chloride or glucose does not influence the measurement and it is possible to apply spectrophotometry in a point-of-care sensor of the Cyclaid® by Apotex level. Full Text: PDF ReferencesL. Taylor, C. J. E. Watson, and J. A. Bradley, "Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy", Crit. Rev. Oncol. Hematol. 56, 23 (2005). CrossRef C. C. Mok, "Calcineurin inhibitors in systemic lupus erythematosus", Best Pract. Res. Clin. Rheumatol. 31, 429 (2017). CrossRef C. E. M. Griffiths et al., "Striae gravidarum in primiparae", Br. J. Dermatol. 155, 1 (2006). CrossRef F. Stucker and D. Ackermann, "Immunsuppressiva - Wirkungen, Nebenwirkungen und Interaktionen", Ther. Umschau. Rev. thérapeutique, 68 ,679 (2011). CrossRef A. Fahr, "Cyclosporin Clinical Pharmacokinetics", Clin. Pharmacokinet. 24, 472 (1993). CrossRef Cyclosporine – UpToDate, DirectLink P. Strakowska, R. Beutner, M. Gnyba et al., "Electrochemically assisted deposition of hydroxyapatite on Ti6A14V substrates covered by CVD diamond films – coating characterization and first cell biological results", Mater Sci Eng C Mater Biol Appl. 59, 624 (2016). CrossRef M. Gnyba, M. S. Wróbel, K. Karpienko et al., "Combined analysis of whole human blood parameters by Raman spectroscopy and spectral-domain low-coherence interferometry", Proc. SPIE 9537, 95371N (2015). CrossRef M. S. Wróbel, M. Gnyba, R. Urniaz et al., "Detection of propofol concentrations in blood by Raman spectroscopy", Proc. SPIE 9537, 95370Z (2015). CrossRef M. Gnyba, et al., "SAVE TO MY LIBRARY Raman spectroscopic investigation of blood and related materials", Proc. SPIE 9448, 944809 (2015). CrossRef H. S. Cho et al., "High frame-rate intravascular optical frequency-domain imaging in vivo", Biomed. Opt. Express 5, 223 (2013). CrossRef T. A. Valdez et al., "Multi-color reflectance imaging of middle ear pathology in vivo", Anal. Bioanal. Chem. 407, 3277 (2015). CrossRef M. Ali Ansari, S. Alikhani, and E. Mohajerani, "A hybrid imaging method based on diffuse optical tomography and optomechanical method to detect a tumor in the biological phantom", Opt. Commun. 342, 12 (2015). CrossRef M. S. Wróbel et al., "Multi-layered tissue head phantoms for noninvasive optical diagnostics", J. Innov. Opt. Health Sci. 08, 1541005 (2015). CrossRef D. A. Skoog, F. J. Holler, and S. R. Crouch, Principles of instrumental analysis, (Belmont, CA, Thomson Brooks/Cole 2007). CrossRef M. Hof, Basics of Optical Spectroscopy in Handbook of Spectroscopy, (Weinheim , Wiley-VCH Verlag GmbH & Co. KGaA 2005). CrossRef M. Marzejon et al,. "Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions", Sensors, 18, 2001 (2018). CrossRef UV-9000 Double Beam UV/VIS, http://en.metash.com/ProductShow_172.html CrossRef