Evidence-base for aspirin as venous thromboembolic prophylaxis following joint replacement

Author:

Jameson S. S.1,Baker P. N.1,Deehan D. J.2,Port A.1,Reed M. R.3

Affiliation:

1. South Tees Hospitals NHS Foundation Trust, Marton Road, Middlesbrough TS4 3BW, UK.

2. Newcastle Hospitals NHS Foundation Trust, Freeman Road, High Heaton, Newcastle upon Tyne, NE7 7DN, UK.

3. Northumbria Healthcare NHS Foundation Trust, Woodhorn Lane, Ashington, NE63 9JJ, UK.

Abstract

The National Institute for Health and Clinical Excellence (NICE) has thus far relied on historical data and predominantly industry-sponsored trials to provide evidence for venous thromboembolic (VTE) prophylaxis in joint replacement patients. We argue that the NICE guidelines may be reliant on assumptions that are in need of revision. Following the publication of large scale, independent observational studies showing little difference between low-molecular-weight heparins and aspirin, and recent changes to the guidance provided by other international bodies, should NICE reconsider their recommendations? Cite this article: Bone Joint Res 2014;3:146–9.

Publisher

British Editorial Society of Bone & Joint Surgery

Subject

Orthopedics and Sports Medicine,Surgery

Reference42 articles.

1. Mortality and implant revision rates of hip arthroplasty in patients with osteoarthritis: registry based cohort study

2. No authors listed. National Joint Registry for England and Wales: 8th Annual Report, 2011. http://www.njrcentre.org.uk/NjrCentre/LinkClick.aspx?fileticket=1TQ%2bEiNejm0%3d& tabid=86& mid=523 (date last accessed 30 October 2013).

3. No authors listed. National Institute for Health and Clinical Excellence: reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in patients admitted to hospital http://www.nice.org.uk/nicemedia/live/12695/47920/47920.pdf (date last accessed 17 April 2014).

4. No authors listed. Surveillance of Surgical Site Infections in NHS Hospitals in England: Health Protection Agency. 2012. http://www.hpa.org.uk (date last accessed 17 April 2014).

5. Enhanced recovery program for hip and knee replacement reduces death rate

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