1. Stoke Mandeville Hospital, Mandeville Road, Aylesbury, Buckinghamshire, HP21 8AL, UK.
2. MRC Clinical Trial Unit, 222 Euston Road, London NW1 2DA, UK.
3. The Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK.
4. University College London Hospital, 235 Euston Road, London, NW1 2BU, UK.