Orthopaedic metals and their potential toxicity in the arthroplasty patient-Reference-Cited by-同舟云学术

Orthopaedic metals and their potential toxicity in the arthroplasty patient

Published:2007-05 Issue:5 Volume:89-B Page:567-573
ISSN:0301-620X
Container-title:The Journal of Bone and Joint Surgery. British volume
language:en
Short-container-title:The Journal of Bone and Joint Surgery. British volume

Author:

Keegan G. M.¹,Learmonth I. D.¹,Case C. P.¹

Affiliation:

1. University of Bristol, Bristol Implant Research Centre, Avon Orthopaedic Centre (lower level), Southmead Hospital, Westbury-on-Trym, Bristol, BS10 5NB, UK.

Abstract

The long-term effects of metal-on-metal arthroplasty are currently under scrutiny because of the potential biological effects of metal wear debris. This review summarises data describing the release, dissemination, uptake, biological activity, and potential toxicity of metal wear debris released from alloys currently used in modern orthopaedics. The introduction of risk assessment for the evaluation of metal alloys and their use in arthroplasty patients is discussed and this should include potential harmful effects on immunity, reproduction, the kidney, developmental toxicity, the nervous system and carcinogenesis.

Publisher

British Editorial Society of Bone & Joint Surgery

Subject

Orthopedics and Sports Medicine,Surgery

Link

https://online.boneandjoint.org.uk/doi/pdf/10.1302/0301-620X.89B5.18903

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