Experience in the treatment of dedifferentiated chondrosarcoma

Author:

Mitchell A. D.1,Ayoub K.1,Mangham D. C.1,Grimer R. J.1,Carter S. R.1,Tillman R. M.1

Affiliation:

1. Royal Orthopaedic Hospital Oncology Service, Woodlands, Northfield, Birmingham B31 2AP, UK.

Abstract

Dedifferentiated chondrosarcoma is a rare, highly malignant variant of chondrosarcoma in which a high-grade spindle-cell sarcoma coexists with a lower-grade chondroid tumour. We have reviewed our experience with this neoplasm in 22 patients, all of whom were treated using modern oncological principles of planned resection and chemotherapy. Despite this the median survival was under nine months and only 18% were alive at five years. Those patients who received chemotherapy, and in whom wide margins of excision were achieved at operation, did best. It is essential to have an accurate preoperative diagnosis in order to plan treatment which may offer a better prospect of cure.

Publisher

British Editorial Society of Bone & Joint Surgery

Subject

Orthopedics and Sports Medicine,Surgery

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