Affiliation:
1. Department of Pathology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK.
Abstract
We reviewed 234 benign solitary schwannomas treated between 1984 and 2004. The mean age of the patients was 45.2 years (11 to 82). There were 170 tumours (73%) in the upper limb, of which 94 (40%) arose from the brachial plexus or other nerves within the posterior triangle of the neck. Six (2.6%) were located within muscle or bone. Four patients (1.7%) presented with tetraparesis due to an intraspinal extension. There were 198 primary referrals (19 of whom had a needle biopsy in the referring unit) and in these patients the tumour was excised. After having surgery or an open biopsy at another hospital, a further 36 patients were seen because of increased neurological deficit, pain or incomplete excision. In these, a nerve repair was performed in 18 and treatment for pain or paralysis was offered to another 14. A tender mass was found in 194 (98%) of the primary referrals. A Tinel-like sign was recorded in 155 (81%). Persistent spontaneous pain occurred in 60 (31%) of the 194 with tender mass, impairment of cutaneous sensibility in 39 (20%), and muscle weakness in 24 (12%). After apparently adequate excision, two tumours recurred. No case of malignant transformation was seen.
Publisher
British Editorial Society of Bone & Joint Surgery
Subject
Orthopedics and Sports Medicine,Surgery
Reference23 articles.
1. Weiss SW, Goldblum JR, Enzinger FM. Benign tumours of the peripheral nerves. In: Weiss S, Goldblum JR, eds. Enzinger and Weiss’s soft tissue tumours. Fourth ed. St. Louis: Mosby, 2001:1111–208.
2. Giannini C. Tumors and tumor-like conditions of peripheral nerves. In: Dyck PJ, Thomas PK, eds. Peripheral Neuropathy. Fourth ed. Philadelphia: Elsevier Saunders, 2005:2585–606.
3. Schwannoma (Neurilemoma) with Malignant Transformation A Rare, Distinctive Peripheral Nerve Tumor
4. Henderson DW, Papadimitriou JM, Coleman M. Ultrastructural appearances of tumours: diagnosis and classification of human neoplasia by electron microscopy. Second ed. Edinburgh: Churchill Livingstone, 1986.
5. Stefansson K, Wollmann R, Jerkovic M. S-100 protein in soft tissue tumors derived from Schwann cells and melanocytes. Am J Pathol 1982;106:261–8.
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