Affiliation:
1. Orthopaedic Research Laboratories of the Royal Victoria Hospital and The University of Montreal; Montreal, Canada
Abstract
1. Osmium tetroxide and nitrogen mustard were injected into normal adult rabbit joints. Within one week widespread chondrocyte necrosis had occurred as evidenced by electron microscopic examination and radioactive proline uptake autoradiography. 2. Initially, the cartilage matrix was intact but three to seven months later the cartilage surface began to disintegrate. 3. These studies indicate that osmium tetroxide and nitrogen mustard are unsuitable agents for chemical synovectomy. 4. They also indicate that there may be a long latent period between cartilage cell death and cartilage destruction, and that the evaluation of any agent for chemical synovectomy must take this into consideration.
Publisher
British Editorial Society of Bone & Joint Surgery
Subject
Orthopedics and Sports Medicine,Surgery
Cited by
29 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Dermal discoloration due to osmium tetroxide;Clinical Toxicology;2023-11-02
2. Ruthenium, Rhodium, Palladium, and Osmium;Patty's Toxicology;2023-06-29
3. Osmium;Handbook on the Toxicology of Metals;2022
4. Osmium absorption after osmium tetroxide skin and eye exposure;Basic & Clinical Pharmacology & Toxicology;2020-06-27
5. Synovectomy of the Elbow;Morrey's the Elbow and its Disorders;2018