Histological Changes in the Lungs of Laboratory Mice Treated with Valsartan and Vitamin E

Abstract

Background: This study was conducted in the Department of Biology, University of Kufa. The objective was to demonstrate the effect of using valsartan on the histological structure of the lung in albino mice and the possibility of reducing these effects by treating the animals with vitamin E. Mice treated with valsartan were aged 7-8 weeks and weighed 26-30 g. Methods: 24 adult male albino mice were divided into 4 groups, with 6 mice in each group. The control group, which is the first group, was injected with NACL (0.1 ml) daily for 30 days, subcutaneously. The second group, the vitamin E treatment group, was injected with vitamin E at a dose of 2 mg/kg daily for 30 days, subcutaneously. The third group was injected with valsartan at a dose of 20 mg/kg daily for 30 days, subcutaneously. In the fourth group, the animals were injected with vitamin E at a dose of 2 mg/kg and valsartan at a dose of 20 mg/kg. After the experiment ended, the mice were all sacrificed. Results: Histological sections of the lungs of the different groups were prepared, and the changes in the histological structure were studied using a light microscope. Conclusion: The results showed the protective role of vitamin E in maintaining the lung histological structure in mice treated with valsartan compared to the control treatment