Formulation and Characterization of Sodium Fusidate Loaded-Silver Nanoparticles as Gel for Topical Applications

Abstract

Background: The application of topical medications to facilitate the healing process and prevent infection continues to be an essential component of treatment for all types of wounds. Methods: Silver nanoparticles loaded with sodium fusidate were produced through chemical reduction using trisodium citrate as the reducing agent. The silver nanoparticles were initially produced and then incorporated into a gel prepared using carbomer 940 and triethanolamine. The sodium fusidate-loaded silver nanoparticles were characterized by pH, polydispersity index (PDI), and globular diameter. Results: The novel formula exhibited a globular diameter of 668.2±0.2 nm, normal homogeneous dispersion (PDI, 0.567±0.002), and a pH of 6.2±0.05. Conclusions: To our knowledge, this is the first sodium fusidate-loaded silver nanoparticles nano-drug delivery system. Its preclinical and clinical applications seem promising.