Chokeberry (×sorbaronia mitschurinii ) extract delays age disturbance of Drosophila melanogaster intestinal barrier-Reference-Cited by-同舟云学术

Chokeberry (×sorbaronia mitschurinii ) extract delays age disturbance of Drosophila melanogaster intestinal barrier

Published:2022-11-03 Issue:4 Volume:0 Page:76-81
ISSN:1994-5655
Container-title:Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences
language:en
Short-container-title:

Author:

Platonova E.,Shaposhnikov M.,Moskalev A.

Abstract

Chokeberry contains a wide range of biologically active substances with potential geroprotective activity. An ethanolic extract of chokeberry ×Sorbaronia mitschurinii (ABE) has previously been found to have a positive effect on the lifespan of Drosophila melanogaster individuals in short-term exposure (two weeks). The present study evaluated the effects of ABE on the integrity of the D. melanogaster intestinal barrier. This indicator is a marker of aging in many model organisms (nematodes, fish, and flies) and its appearance correlates with the risk of age-dependent death. Brilliant Blue FCF, a synthetic blue food coloring, was used as an indicator of intestinal barrier permeability. It was found that ABE applied before the age of 2 weeks did not significantly affect the integrity of the intestinal barrier in D. melanogaster males and females. However, treatment with ABE at the age of 4-5 weeks resulted in a 3-fold reduction (p < 0.05) in females with compromised intestinal barrier integrity at 8 weeks of age compared to untreated females of the same age. Thus, the use of chokeberry fruit extract in middle age leads to a delay in the onset of age-dependent defects of the integrity of the D. melanogaster intestinal barrier.

Publisher

Komi SC UB RAS

Subject

General Earth and Planetary Sciences,General Energy

Reference21 articles.

1. Hallmarks of Health / C. López-Otín, G. Kroemer // Cell. – 2021. – Vol. 184, N 1. – P. 33-63., Hallmarks of Health / C. López-Otín, G. Kroemer // Cell. – 2021. – Vol. 184, N 1. – P. 33-63.

2. Intestinal permeability – a new target for disease prevention and therapy / S. C. Bischoff, G. Barbara, W. Buurman, T. Ockhuizen, J. D. Schulzke, M. Serino, H. Tilg, A. Watson, J. M. Wells // BMC Gastroenterol. – 2014. – Vol. 14 – P. 189., Intestinal permeability – a new target for disease prevention and therapy / S. C. Bischoff, G. Barbara, W. Buurman, T. Ockhuizen, J. D. Schulzke, M. Serino, H. Tilg, A. Watson, J. M. Wells // BMC Gastroenterol. – 2014. – Vol. 14 – P. 189.

3. Citrus flavonoids and the intestinal barrier: Interactions and effects / M. Wang, H. Zhao, X. Wen, C. T. Ho, S. Li // Compr Rev Food Sci Food Saf. – 2021. – Vol. 20, N 1. – P. 225-251., Citrus flavonoids and the intestinal barrier: Interactions and effects / M. Wang, H. Zhao, X. Wen, C. T. Ho, S. Li // Compr Rev Food Sci Food Saf. – 2021. – Vol. 20, N 1. – P. 225-251.

4. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog / M. Rera, S. Bahadorani, J. Cho, C. L. Koehler, M. Ulgherait, J. H. Hur, W. S. Ansari, T. Lo, Jr., D. L. Jones, D. W. Walker // Cell Metab. – 2011. – Vol. 14, N 5. – P. 623-634., Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog / M. Rera, S. Bahadorani, J. Cho, C. L. Koehler, M. Ulgherait, J. H. Hur, W. S. Ansari, T. Lo, Jr., D. L. Jones, D. W. Walker // Cell Metab. – 2011. – Vol. 14, N 5. – P. 623-634.

5. Dietary polyphenols can modulate the intestinal inflammatory response / B. Romier, Y.-J. Schneider, Y. Larondelle, A. During // Nutrition Reviews. – 2009. – Vol. 67, N 7. – P. 363-378., Dietary polyphenols can modulate the intestinal inflammatory response / B. Romier, Y.-J. Schneider, Y. Larondelle, A. During // Nutrition Reviews. – 2009. – Vol. 67, N 7. – P. 363-378.