Adsorption of Albumin and Creatinine on ZnO Nanoparticles

Abstract

This study focused on the adsorption of albumin and creatinine on the surface of zinc oxide nanoparticles. Factors affecting adsorption, like contact time, adsorbent dose, concentration, temperature, PH, and shaking rate, were studied. The best conditions for adsorption were found at 298k, pH = (7), the concentration of (2.25, 0.5x10-3)g/dL, (30, 2.5)min, and weight of zinc oxide NPs (30, 10)mg for both albumin and creatinine respectively. We found that adsorption corresponds to Langmuir adsorption isotherms for albumin and Temkin adsorption isotherms for creatinin. Thermodynamic parameters were determined (average of ΔG = -12563.57(J/mol.K), ΔH = 25.740(kJ/mol), average of ΔS = 126.37(J/mol)) for albumin and (average of ΔG = -3348.45(J/mol.K), ΔH = 36.731(kJ/mol), average of ΔS = 132.22(J/mol)) for creatinine, Through the results of )ΔG(, the system is spontaneous because of the negative values. Positive ) ΔH( value clarify that process is endothermic. While ΔS value refers to the system is more random, the results also show that the adsorption type was physical, which means that it is multilayered. The type of bonding force between the molecules is Vander Waals force.