Formulation and Development of Novel Matrix Dispersion System based on Phospholipid Complex for Improving Oral Bioavailability of Ferulic Acid

Abstract

The usage of phospholipid complexes is one of the greatest ways to increase the oral poorly absorbed plant parts’ bioavailability components. However, the stickiness of due to the phospholipids, the inefficient breakdown of medications. To make the ferulic acid phospholipid complex (FAPLC) more dispersible and to create a dispersion of a matrix of ferulic acid according to the phospholipid complex (MD-FAPLC) utilizing a solvent evaporation method, pentaerythritol was used in this study. Pentaerythritol, phospholipid, and ferulic acid were mixed in a 1:2:5 ratio. Penta erythritol is used to enhance dissolving and as a dispersion agent. The study done on fourier-transform infrared spectroscopy (FTIR) and calorimetry that uses differential scanning (DSC) investigations of the ferulic acid in MD-FAPC. The solubilities of ferulic acid in water and N-octanol were significantly higher in MD-FAPC than in pure ferulic acid (FA). At 120 minutes, MD-cumulative FAPLC’s dissolution was more than that of FA and FAPC and greater than that of pure FA. The story MD -FAPLC increased the oral bioavailability of FA by enhancing its permeability and solubility while maintaining its complex state with phospholipids.