Author:
. Himanshu,Bhaskar Rahul,Sharma Neelam,Mehta Mohit,Singh Amrik,. Yashwant,Yadav Narendra,Khatik Gopal,Verma Surajpal
Abstract
The present research article represents the formulation and evaluation of buccoadhessive film of ropinirole hydrochloride.
This drug is an oral non-ergoline dopamine agonist with the greater affinity at D3 receptor. This drug having low
molecular weight (296.84 g/mol), and short biological half-life (4-6 hrs) which necessitates for multiple dosing for
maintaining therapeutic effect throughout the day. Moreover, drug is metabolized in liver forming several inactive
metabolites which decrease it oral bioavailability upto 50% making it a suitable candidate for administration of drug
through buccal mucosa. Buccal films of ropinirole hydrochloride were prepared using various polymers (HPMC, EC,
PVA and Carbopol) by solvent casting method using propylene glycol as plasticizer. These films were evaluated for
various parameter such as appearance, surface texture, weight uniformity, thickness, folding endurance, surface pH, drug
content and swelling index. All the formulations were subjected to in vitro drug release study which were carried out
using egg membrane as semi permeable membrane.
Publisher
Dr. Yashwant Research Labs Pvt. Ltd.
Cited by
2 articles.
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