A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance-Reference-Cited by-同舟云学术

A novel HIV-1 protease inhibitor, GRL-044, has potent activity against various HIV-1s with an extremely high genetic barrier to the emergence of HIV-1 drug resistance

Published:2019-10-31 Issue:1 Volume:1 Page:36-48
ISSN:2434-9186
Container-title:Global Health & Medicine
language:en
Short-container-title:GHM

Author:

Aoki Manabu¹²,Chang Simon B.¹,Das Debananda¹,Martyr Cuthbert³,Delino Nicole S.¹,Takamatsu Yuki¹,Ghosh Arun K.³,Mitsuya Hiroaki¹²⁴

Affiliation:

1. Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

2. Department of Refractory Viral Infections, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.

3. Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, IN, USA.

4. Deprtment of Clinical Sciences, Kumamoto University Hospital, Kumamoto, Japan.

Publisher

National Center for Global Health and Medicine (JST)

Link

https://www.jstage.jst.go.jp/article/ghm/1/1/1_2019.01003/_pdf

Reference38 articles.

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3. 3. Feng M, Sachs NA, Xu M, Grobler J, Blair W, Hazuda DJ, Miller MD, Lai MT. Doravirine Suppresses Common Nonnucleoside Reverse Transcriptase Inhibitor-Associated Mutants at Clinically Relevant Concentrations. Antimicrob Agents Chemother. 2016; 60:2241-2247.

4. 4. Khalilieh S, Yee KL, Sanchez RI, Triantafyllou I, Fan L, Maklad N, Jordan H, Martell M, Iwamoto M. Results of a doravirine-atorvastatin drug-drug interaction study. Antimicrob Agents Chemother. 2017. 61. doi: 10.1128/AAC.01364-16.

5. 5. Yang LL, Li Q, Zhou LB, Chen SQ. Meta-analysis and systematic review of the efficacy and resistance for human immunodeficiency virus type 1 integrase strand transfer inhibitors. Int J Antimicrob Agents. 2019. doi: 10.1016/j.ijantimicag.2019.08.008.

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