A novel protocol for de-isolating moderately and severely immunocompromised COVID-19 patients

Author:

Kamegai Kohei1,Iwamoto Noriko1,Ishikane Masahiro1,Yamamoto Kei1,Horii Kumi2,Kubota Shiho2,Hangaishi Akira3,Shimazu Hiroshi3,Togano Tomiteru3,Yamashita Hiroyuki4,Yamada Yasuhide5,Ohmagari Norio1

Affiliation:

1. Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.

2. Infection Control Office, National Center for Global Health and Medicine, Tokyo, Japan.

3. Department of Hematology, National Center for Global Health and Medicine, Tokyo, Japan.

4. Division of Rheumatic Diseases, National Center for Global Health and Medicine, Tokyo, Japan.

5. Comprehensive Cancer Center, National Center for Global Health and Medicine, Tokyo, Japan.

Publisher

National Center for Global Health and Medicine (JST)

Subject

General Medicine

Reference27 articles.

1. 1. Centers for Disease Control and Prevention. Interim infection prevention and control recommendations for healthcare personnel during the coronavirus disease 2019 (COVID-19) pandemic. https://www.cdc.gov/coronavirus/2019-ncov/hcp/infection-control-recommendations.html (accessed August 27, 2023).

2. 2. Centers for Disease Control and Prevention. Interim clinical considerations for use of COVID-19 vaccines in the United States. https://www.cdc.gov/vaccines/covid-19/clinical-considerations/interim-considerations-us.html#immunocompromised (accessed April 8, 2023).

3. 3. Sepulcri C, Dentone C, Mikulska M, et al. The longest persistence of viable SARS-CoV-2 with recurrence of viremia and relapsing symptomatic COVID-19 in an immunocompromised patient-A case study. Open Forum Infect Dis. 2021; 8:ofab217.

4. 4. IDSA and AMP joint statement on the use of SARS-CoV-2 PCR cycle threshold (Ct) values for clinical decisionmaking. Updated March 12, 2021. https://www.idsociety.org/globalassets/idsa/public-health/covid-19/idsa-amp-statement.pdf (accessed April 8, 2023).

5. 5. Apostolidis SA, Kakara M, Painter MM, et al. Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nat Med. 2021; 27:1990-2001.

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