Nucleos(t)ide reverse transcriptase inhibitor-sparing regimens in the era of standard 3-drug combination therapies for HIV-1 infection

Author:

Uchitsubo Keita1,Masuda Junichi1,Akazawa Tsubasa1,Inoue Risako1,Tsukada Kunihisa2,Gatanaga Hiroyuki2,Terakado Hiroyuki1,Oka Shinichi2

Affiliation:

1. Pharmaceutical Department, National Center for Global Health and Medicine, Tokyo.

2. AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo.

Publisher

National Center for Global Health and Medicine (JST)

Reference11 articles.

1. 1. Department of Health and Human Services. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. https://aidsetc.org/resource/guidelines-use-antiretroviral-agents-hiv-1-infected-adults-and-adolescents (accessed May 27, 2020).

2. 2. Taiwo B, Zheng L, Gallien S, Matining RM, Kuritzkes DR, Wilson CC, Berzins BI, Acosta EP, Bastow B, Kim PS, Eron JJ Jr. Efficacy of a nucleoside-sparing regimen of darunavir/ritonavir plus raltegravir in treatment-naive HIV-1-infected patients (ACTG A5262). AIDS. 2011; 25:2113-2122.

3. 3. Calza L, Danese I, Magistrelli E, Colangeli V, Manfredi R, Bon I, Re MC, Conti M, Viale P. Dual raltegravir–darunavir/ritonavir combination in virologically suppressed HIV-1-infected patients on antiretroviral therapy including a ritonavir-boosted protease inhibitor plus two nucleoside/nucleotide reverse transcriptase inhibitors. HIV Clin Trials. 2016; 17:38-47.

4. 4. Llibre JM, Hung CC, Brinson C, Castelli F, Girard PM, Kahl LP, Blair EA, Angelis K, Wynne B, Vandermeulen K, Underwood M, Smith K, Gartland M, Aboud M. Efficacy, safety, and tolerability of dolutegravir-rilpivirine for the maintenance of virological suppression in adults with HIV-1: phase 3, randomised, non-inferiority SWORD-1 and SWORD-2 studies. Lancet. 2018; 391:839-849.

5. 5. Nishijima T, Gatanaga H, Shimbo T, et al. Switching tenofovir/emtricitabine plus lopinavir/r to raltegravir plus darunavir/r in patients with suppressed viral load did not result in improvement of renal function but could sustain viral suppression: A randomized multicenter trial. PLoS One. 2013; 8:e73639.

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