Prostat Adenokarsinomunun tanı ve prognostik sınıflandırmasında CCR3 ekspresyonunun değeri

Abstract

Objective: Chemokines are factors secreted from damaged or infected tissues to induce an inflammatory and immunological reaction. Approximately Chemokines have recently been found to be secreted by most cancer cells. The aim of this study is to compare the CCR-3 expression with the clinicopathological variables in patients with prostatic adenocarcinoma(PCa) and benign prostatic hyperplasia(BPH). Material Method: The study included 25 patients with PCa who underwent prostatectomy, 25 patients with BPH. In the study, CCR-3 expression in PCa and BPH tissues was examined by immunohistochemical method, and CCR-3 expression at PCA and BPH tissues was compared with normal prostate tissue at mRNA level by the Real-Time PCR. Results: CCR-3 expression was found to be significantly higher in PCa patients (p=0,001). There was no relationship between Gleason prognostic grade and periprostatic spread and CCR-3 expression (p=0,887, p=0,279). A statistically significant increase was found in total PSA and CCR-3 expression (p=0,001). Conclusion: In prostate cancer, expression of the CCR3 receptor is associated with the occurrence of aggressive disease with extended local dissemination and a higher risk of biochemical recurrence. According to this study, the CCR-3 expression may be useful in predicting the diagnosis of PCa and there was a significant relationship between total PSA. The Increasing total PSA was also correlation to increased of the CCR3 expression. However, there was no significant relationship between Gleason prognostic grade.