1. OS; reactive oxygen species, ROS; mitochondrial-derived ROS, mROS; glutathione, GSH; glucose-6-phosphate dehydrogenase, G6PD; solute carrier family 7 member 11, SLC7A11; pentose phosphate pathway, PPP; Gene Expression Omnibus, GEO; small interfering RNA, siRNA; fetal bovine serum, FBS; Medroxyprogesterone acetate combined with 8-bromo-cAMP sodium salt, MPA+cAMP; SLC7A11 short hairpin interfering RNA, Si-SLC7A11; G6PD short hairpin interfering RNA, Si-G6PD; negative control, Si-NC; liquid chromatographymass spectrometry, LC/MS; mass spectrometry, MS; Ultra-High Performance Liquid Chromatography, UPLC; semi-quantitative grading system, H-score; Enzyme-linked immunosorbent assay, ELISA; human prolactin, PRL; extracellular acidification rate, ECAR; 2-deoxy-D-glucose, 2-DG; Glutathione Reductase, GR; Glutathione Peroxidase, GPX; oxidized glutathione, GSSG; least significant difference, LSD; insulin like growth factor binding protein 1;IGFBP