1. TNF signaling pathway" and" NF-kappa B signaling pathway" were dominating after the co-exposure of CS and BaP in mice lung (Fig.3). NOD-like receptor (NLR) signaling pathway (including pattern recognition receptor, inflammasome, caspase-1 and related inflammatory factors) is an important immune defense mechanism, which can recognize and respond to a variety of foreign pathogens, cell damage and own nucleic acids and other danger signals. Numerous studies have proved the important role of NLRP3 and NLRP1 inflammasomes in CS-induced;Moledina;M1 macrophages in many inflammation and immune processes,2023
2. In turn, TNF-? promoted CS-mediated caspase-1 activation and IL-1? secretion (Liu et al. 2021). BaP exposure also elevated the level of pro-inflammatory cytokines by increasing the expression of NF-?B;Consistently, data from PPI analysis showed that Casp1 and NLR family (including Nlrp1, Nlrp3,2017
3. Amelioration of Benzo[a]pyrene-induced oxidative stress and pulmonary toxicity by Naringenin in Wistar rats: A plausible role of COX-2 and NF-kappaB;R Ali;Hum Exp Toxicol,2017
4. Simple method of estimating severity of pulmonary fibrosis on a numerical scale;T Ashcroft;J Clin Pathol,1988
5. Protective effects of piperlongumin in the prevention of inflammatory damage caused by pulmonary exposure to benzopyrene carcinogen;Teb Ashino;Int Immunopharmacol,2021