Structurally Diverse Diterpenoids from Isodon Oresbius and Their Bioactivity

Author:

Qiu Cai-Ling,Ye Zhen-Nan,Yan Bing-Chao,Hu Kun,Yang Jin,Yang Xing-Zhi,Li Hong-Mei,Li Xiao-Nian,Sun Han-Dong,Puno Pema-Tenzin

Publisher

Elsevier BV

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference70 articles.

1. :1) to give six subfractions (B2a-B2f) based on TLC analysis. Then, subfraction B2d (79 g) was subjected to RP-18 silica gel CC (MeOH-H 2 O, 30:70 to 100:0) to provide four fractions, B2d-1-B2d-4. Fr. B2d-1 was subjected to preparative HPLC (5 mL/min, detector UV ? max 210 nm, CH 3 CN-H 2 O, 30:70;isoresbin F (6, 0.98 mg), isoresbin H (8, 0.69 mg), isoresbin I (9, 3.16 mg), laxiflorin G (0.87 mg), and 6?,2002

2. mL/min, detector UV ? max 210 nm, CH 3 CN-H 2 O, 22:78) to yield isoresbin C (3, 28.72 mg), isoresbin D (4, 27.25 mg), isoresbin J (10, 0.96 mg), lushanrubescensin F (1.63 mg), lasiodonin (9.8 mg), lasiokaurin (2.4 mg), isorosthin L (9.2 mg), effusanin E (5.47 mg), effusanin A (7.84 mg), isojaponin A (1.73 mg), laxiflorolide S (12.0 mg), and isodoternifolin B (2.1 mg). Fr. C1a-10 was purified by semi-preparative HPLC to give adenolin E (6.22 mg), parvifoline I (50 mg);C1a-8 was purified by semi-preparative HPLC

3. 07) nm; IR (KBr) ? max 3433;Uv (meoh) ? Max;cm -1 ; 1 H and 13 C NMR data, see Tables 1 and 2; positive HRESIMS [M + H] + m/z 405.1907 (calcd for C 22 H 29 O 7,1047

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