Site-Specific N-Terminal Pegylation-Based Controlled Release of Biotherapeutics: An Application for Glp-1 Delivery to Improve Pharmacokinetics and Prolong Hypoglycemic Effects

Author:

Lin Qianmeng,Xia Xuan,Li Jun,Zhou Zhan,Chen Yongheng

Publisher

Elsevier BV

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference34 articles.

1. Therapeutic protein-polymer conjugates: advancing beyond PEGylation;E M Pelegri-O'day;Journal of the American Chemical Society,2014

2. A Concise Approach to Site-Specific Topological Protein-Poly(amino acid) Conjugates Enabled by in Situ-Generated Functionalities;Y Hou;Journal of the American Chemical Society,2016

3. Polymers for protein conjugation;G Pasut;Polymers,2014

4. Drug and protein delivery by polymer conjugation;A Grigoletto;Journal of Drug Delivery Science and Technology,2016

5. Site-selective modification of exendin 4 with variable molecular weight dextrans by oxime-ligation chemistry for improving type 2 diabetic treatment;S Dai;Carbohydr Polym,2020

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