Jiao-Tai-Wan and its Effective Component-Coptisine Alleviate Cognitive Impairment in Db/Db Mice Through the Jak2/Stat3 Signaling Pathway

Author:

Nie Kexin,Gao Yang,Wang Hongzhan,Su Hao,Chen Shen,Jiang Xinyue,Dong Hui,Tang Yueheng

Publisher

Elsevier BV

Reference47 articles.

1. Effects of JTW on peripheral inflammation and neuroinflammation in db/db mice. (A-C) The levels of TNF-?, IL-6 and IL-1? in the serum of mice in different groups;* P<0;05, **P<0.01; compared with the model group, #P<0.05, ##P<0.01. Fig 5

2. Effects of coptisine on the JAK2/STAT3 signaling pathway in BV2 cells. (A) Representative western blots of JAK2, p-JAK2, STAT3, pSTAT3 and SOCS3 protein expressions in BV2 cells; (B-F) The quantification of JAK2, p-JAK2, STAT3, pSTAT3 and SOCS3 protein in BV2 cells by Western blots (n = 4). (G-H) The mRNA expression levels of JAK2 and STAT3 in BV2 cells (n = 6). All data are presented as means � SEM;G) ; H-J;#P<0.05, ##P<0.01, ###P<0.001. Fig 9

3. Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia;A Areosa Sastre;Cochrane Database Syst Rev,2017

4. Anti-depressive effects of Jiao-Tai-Wan on CORT-induced depression in mice by inhibiting inflammation and microglia activation;G Bai;J Ethnopharmacol,2022

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