Photochemical Generation of Ketenes from Phenanthrene-Based Cyclobutanones

Author:

Thamattoor Dasan M.,Roth Alexander D.,Koldasbay Zhazira,Ford Brett H.,Kairbek Khaidar,Ahn Heejoon,Hardikar Tarini S.,Lane Katherine M.,Haynes Sarah M.

Publisher

Elsevier BV

Reference27 articles.

1. Yields of the ester 30a (3.61 mg, 0.0134 mmol, 33%) and phenanthrene (6.80 mg, 0.0382 mmol, 94%) were thus determined. Bii. Photolysis of 18 in benzylamine: Precursor 18 (150 mg, 0.441 mmol) and benzylamine (92.1 �L, 90.4 mg, 0.845 mmol) were dissolved in benzene (4.5 mL) in a quartz pressure tube. Photolysis was monitored by GC-MS and TLC until all 18 had reacted, or 6 hrs. The amide (30b) was isolated using silica-gel flash column chromatography (0:100 ? 50:50 ethyl acetate:hexanes) in a 31% yield. Biii. Photolysis of 18 in benzylamine and m-xylene: Precursor 18 (13.0 mg, 0.0384 mmol) was dissolved in C 6 D 6 (0.5 mL) in a quartz NMR tube;Photolysis was monitored by NMR until all 18 had reacted

2. 85 mg, 0.0366 mmol, 95%) and phenanthrene (6.59 mg, 0.0370 mmol, 96%) were thus determined. Biv. Photolysis of 18 without an internal trap: Precursor 18 (30.0 mg, 0.0881 mmol) was dissolved in benzene (2 mL) in a long-necked quartz cuvette. The solution was photolyzed for 7 hrs, checking via GC-MS once every hour. Ketene 13 was observed, along with a minor amount of 2-adamantanone and trace amounts of 2-adamantylcarboxylic acid. The addition of benzylamine (1 mL) to the photolysate and immediate analysis with GC-MS showed full References (1) Roth;Org. Biomol. Chem,2023

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