1. In the absence of WWOX, endogenous TRAF2 in Wwox -/-knockout MEF cells did not relocate to the nucleus in response to UV/cold shock (Fig. 6H), suggesting that TRAF2 requires WWOX to co-translocate to the nucleus. By co-immunoprecipitation, UV/cold shock induced the dissociation of the endogenous WWOX/TRAF2 complex in 30 min in COS7 cells (Fig. 6I). TRADD, a TNF receptor adaptor protein;Li;the EGFP-TRAF2/DsRedM-WWOX complex became dissociated in 60 min (Fig. 6F),2005
2. The height of each bubble is about one-fifth of the cell. The bubble can be detached from the cell and released to the extracellular surface, or it continues to stay on the cell surface. This occurs normally in small cells of less References Aldaz;Chen Chang;Int. J. Mol. Sci,2015
3. Glutathione peroxidases and redox-regulated transcription factors;R Brigelius-Floh�;Biol. Chem,2006
4. WWOX dysfunction induces sequential aggregation of TRAPPC6A?, TIAF1, tau and amyloid ?, and causes apoptosis;J Y Chang;Cell Death Discov,2015