Design and Optimization of Oestrogen Receptor PROTACs Based on 4-Hydroxytamoxifen
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Published:2022
Issue:
Volume:
Page:
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ISSN:1556-5068
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Container-title:SSRN Electronic Journal
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language:en
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Short-container-title:SSRN Journal
Author:
Riera Antoni,Loren Guillem,Espuny Irene,Llorente Alicia,Donoghue Craig,Verdaguer Xavier,Gomis Roger R.
Subject
General Earth and Planetary Sciences,General Environmental Science
Reference111 articles.
1. The crude was purified by flash column chromatography; the product eluted at 3% MeOH/DCM yielding TAM-PO-2 (18 mg, 0.02 mmol, 30% yield) as a yellow solid;Ethyl;The product was prepared following the general procedure starting from alkyne 1 and 4