1. Wuling San pretreatment significantly downregulated CYP2E1 and HO-1 levels after CDDP exposure. The foregoing outcomes suggest that Wuling San administration protects kidneys against CDDP-induced oxidative stress. The inflammatory response is a generally recognized mechanism of CDDP-induced nephrotoxicity. Long-term overexpression of proinflammatory cytokines and cell mediators may exacerbate kidney damage (Pabla and Dong;Li;Similarly, we found that Wuling San pretreatment downregulated NF-?B p65, TNF-?, IL-1?, COX-2, and iNOS levels References,2008
2. Clinical study of Wuling Son in the treatment of chemotherapy-induced renal failure;J H Cheng;Zhong Yi Za Zhi,1993
3. Protective effects of traditional herbal formulas on cisplatin-induced nephrotoxicity in renal epithelial cells via antioxidant and antiapoptotic properties;V K Dachuri;Evid. Based Complement. Alternat. Med,2020
4. Cisplatin in cancer therapy: molecular mechanisms of action;S Dasari;Eur. J. Pharmacol,2014
5. Wuling San ameliorates urate under-excretion and renal dysfunction in hyperuricemic mice;X Q Ding;Chin. J. Nat. Med,2013