1. affecting wild-type cysteine residues, 90 affecting the animal peroxidase domain and 38, the remaining TPO monomer), 11 nonsense variants, 5 duplications (3 singles and 2 multiple), 24 deletions (12 singles, 10 multiples and 2 involving a large number of nucleotides), 1 multiple nucleotide insertion/deletion and 12 splice site (ss) variants (6 in the acceptor ss and 6 in the donor ss);Abramowicz,1992