1. After that, the intensity of fluorescence signal is gradually weakening over time, but its fluorescence can be still detectable after 24 hours. However, the fluorescence intensity in the mice treated with Cy5.5-labelled Met/GOx@His/ZIF-8 is lower than that of Cy5.5-labelled Met/GOx@His/ZIF-8~RGD-treated mice at each test time point, indicating that Met/GOx@His/ZIF-8~RGD can accumulate in tumors rapidly and exhibit long-term tumor retention. According to the fluorescence images and quantitative analysis of the main organs and tumor tissues in Figures 6c and S15, Met/GOx@His/ZIF-8~RGD can be more effectively accumulated in tumors than Met/GOx@His/ZIF-8. Besides, the fluorescence signal in the liver of Met/GOx@His/ZIF-8-treated mice is stronger than that of Met/GOx@His/ZIF-8~RGD-treated mice, demonstrating that Met/GOx@His/ZIF-8 is metabolized through the liver rather than accumulated in tumor. The in vivo tumor inhibition ability of Met/GOx@His/ZIF-8~RGD was determined using the breast tumor-bearing nude mice;Cy5.5-labelled Met/GOx@His/ZIF-8 or Cy5.5-labelled Met/GOx@His/ZIF-8~RGD were intravenously injected into the mice. The strongest fluorescence signals can be observed after the injection with Cy5.5-labelled Met/GOx@His/ZIF-8~RGD for 4 h (Figures 6a and 6b)
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