1. In the study by Leonarski et al. [57], these authors assessed the cytotoxicity of the pressurized-liquid/heating-stirring extracted anthocyanin, showing a decrease in L929 cell viability (around 80%) at concentrations of 250 ?g mL -1 within 24 h. On the contrary, the L929 cell viability increased to approximately 130% when exposed to grape phenolic compounds-rich extracts at a concentration of 25 ?g mL -1 [58]. The same phenomenon was also observed in various cell lines (L929, RAW264.7 and PC12) treated with polysaccharides from different origins. In these studies [59-61], the cell viability exceeded 100% at appropriated polysaccharide concentrations during the culture period;DES concentrations up to 1 �L mL -1 . At DES concentrations ? 10 �L mL -1 , the cell viability significantly decreased (P < 0.05)
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