PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-Specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia

Author:

Borras Carla,Canyelles Marina,Girona Josefa,Ibarretxe Daiana,Santos David,Revilla Giovanna,Llorente-Cortés Concepción Vicenta,Rotllan Noemí,Kovanen Petri T.,Jauhiainen Matti,Lee-Rueckert Miriam,Masana Luis,Arrieta Francisco,Martínez-Botas Javier,Gómez-Coronado Diego,Ribalta Josep,Tondo Mireia,Blanco-Vaca Francisco,Escola-Gil Joan Carles

Publisher

Elsevier BV

Reference48 articles.

1. Liver [ 3 H]cholesterol at 48h in LDLR+/+ hAPOB100 mice. Liver weights were 1.68 � 0.30 g and 1.32 � 0.35 g in LDLR+/+ hAPOB100 treated with the vehicle and PCSK9-mAb1-treated mice;LDL cholesterol levels present in the non-HDL fraction

2. g in LDLR+/-hAPOB100 treated with the vehicle and PCSK9-mAb1-treated mice, respectively (p=0.2130). (G) [ 3 H]cholesterol + [ 3 H]bile acids in the feces collected over 48 h in LDLR+/-hAPOB100 mice;H] Ldl;LDL cholesterol levels between both groups. An unpaired t-test was performed to compare total liver

3. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society;B G Nordestgaard;Eur Heart J,2013

4. Prevalence of Familial Hypercholesterolemia Among the General Population and Patients With Atherosclerotic Cardiovascular Disease: A Systematic Review and Meta-Analysis;P Hu;Circulation,2020

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