Author:
Dobre Daniela,Schwan Raymund,Jansen Claire,Schwitzer Thomas,Martin Olivier,Ligier Fabienne,Rolland Benjamin,Abdel-Ahad Pierre,Capdevielle Delphine,Corruble Emmanuelle,Delamillieure Pascal,Dollfus Sonia,Drapier Dominique,Bennabi Djamila,Joubert Fabien,Lecoeur William,Massoubre Catherine,Pelissolo Antoine,Roser Mathilde,Schmitt Christophe,Teboul Noe,Vansteene Clément,Yekhlef Wanda,Yrondi Antoine,Haoui Radoine,Gaillard Raphael,Leboyer Marion,Thomas Pierre,Gorwood Philip,Laprevote Vincent
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1. Several mechanisms of 444 neurological manifestations have been presented, including the direct neurotropism of the 445 coronavirus (direct injury), the hypoxic mechanism via the damage of the pulmonary tissue 446 (indirect hypoxic neuronal injury), or the immune-mediated (indirect) neuronal injury 447 mechanism, mainly due to increased levels of inflammatory cytokines and activation of T-448 lymphocytes 18,19,22 . Patients with severe psychiatric disorders may be at particular risk of this 449 syndrome, due to the mechanisms inherent to their pathology and its treatment. pneumonia 29,30 . However, Farsalinos et al. recently showed In Silico that there was 464 an interaction between SARS-Cov-2 and nicotinic receptors, which could implicate a 465 protective role of nicotine against SARS-Cov-2 31 . Beside these findings, several studies 466 reported that nicotine inhibits the production of pro-inflammatory cytokines (TNF-?, IL-1, 467 and IL-6) 32,33 , and these effects have been shown to protect against cytokine;Despite their relatively young age, the patients in our study presented a broad range of 424 comorbidities, including hypertension (20%), diabetes (12%), and neurological disorders 425 (7%)