1. Under optimized conditions, this biosensor can detect as low as 8.5 fM and 1 CFU/mL as the detection limit, respectively for Pb 2+ and S. aureus. Besides, this biosensor holds high selectivity, accuracy and good anti-interference ability. Prospectively, the biosensor enables the detection of other analysts by re-designing the sequence of the DNAzyme or aptamer. CRediT authorship contribution statement Yi Li: Methodology, Conceptualization, Writing-original draft, Validation. Yupeng Ying: Conceptualization, Formal analysis;Mengyuan Sun: Investigation, Visualization. Huixin Wang: Validation, Formal analysis. Tingting Sun: Formal analysis. Wei Qu: Validation, Resources. Dongmei Chen: Writing-review & editing, Supervision
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