1. Passive membrane properties i.e. B) Resting membrane potential (RMP). C) Membrane time constant and D) Membrane capacitance were not altered by Grin1 deletion. A significant change was observed in E) Input resistance [163.1�9.8 M? for control (n=7); vs 236�22.8 M? for Ppp1r2cre/Grin1 KO (n=9) *p=0.02, One-way Anova; 174.1�17.2 M? for PVcre/Grin1 KO (n=11), p=0.88, One-way Anova vs control], F) AP threshold [44.57�2.16 (-)mV for control (n=7); vs 33.32�2.54 (-)mV for Ppp1r2cre/Grin1 KO (n=9), *p=0.02, One-way Anova; 45.10�1.33 (-)mV for PVcre/Grin1 KO (n=11), p=0.99, One-way Anova vs control], G) spiking adaptation index (ratio of Inter-spike interval 1 and 15 in a train of APs;for control (n=7); vs 0.41�0.06 for Ppp1r2cre/Grin1 KO (n=9), *p=0.0045, One-way Anova; 0.56�0.02 for PVcre/Grin1 KO (n=11)
2. Representative traces show kinetics of AP from the indicated groups. L) AP firing frequencies of control, Ppp1r2cre/Grin1 KO and PVcre/Grin1 KO mice in response to 500ms-current injection of 0 to 500 pA with 25 pA step, Ppp1r2cre/Grin1 KO mice REFERENCES;J E Belforte;Nat Neurosci,2010
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