Author:
Koka Sweta S,Gayakwad Devshree,Shraddha ,Kadam Sonali Santosh,Jha Ritesh,Kumar Anil,Otia Mihir Kedarbhai
Abstract
Objectives: This study's objective was to investigate whether or not a methanolic extract of Mallotus japonicas could decrease H+-K+ ATPase activity and neutralise acid. Materials and Methods: We assessed the total phenolic and flavonoid contents of the sample while it was exposed to varying amounts of standard esmoprazole and methanol extract. Results: The proton pump inhibitory activity of the extract from stomach mucosal homogenate was found to be significant (*P<0.05) and on par with the standard. Conclusions: Based on these findings, it may be concluded that the proton pump can be effectively blocked by the methanolic extract.
Reference44 articles.
1. Chiarelli-Neto O, Ferreira AS, Waleska KM, Pavani C, Severino D, Faião-Flores F, et al. Melanin photosensitization and the effect of visible light on epithelial cells. PLoS One 2014; 9(11): e113266.
2. Awuchi, C. G., Amagwula, I. O., Priya, P., Kumar, R., Yezdani, U., & Khan, M. G. (2020). Aflatoxins in foods and feeds: A review on health implications, detection, and control. Bull. Environ. Pharmacol. Life Sci, 9, 149-155.
3. Ogura R, Sugiyama M, Nishi J, Haramaki M. Mechanism of lipid radical formation following exposure of epidermal homogenate to ultraviolet light. J Invest Dermatol 1991; 97(6): 1044-7.
4. Kumar, R., Saha, P., Lokare, P., Datta, K., Selvakumar, P., & Chourasia, A. (2022). A Systemic Review of Ocimum sanctum (Tulsi): Morphological Characteristics, Phytoconstituents and Therapeutic Applications. International Journal for Research in Applied Sciences and Biotechnology, 9(2), 221-226.
5. Taira J, Mimura K, Yoneya T, Hagi A, Murakami A, Makino K. Hydroxyl radical formation by UV-irradiated epidermal cells. J Biochem 1992; 111(6): 693-5.