Edge Effect in Hot Embossing and its Influence on Global Pattern Replication of Polymer-Based Microneedles-Reference-Cited by-同舟云学术

Edge Effect in Hot Embossing and its Influence on Global Pattern Replication of Polymer-Based Microneedles

Published:2019-04-18 Issue:2 Volume:34 Page:231-238
ISSN:2195-8602
Container-title:International Polymer Processing
language:en
Short-container-title:

Author:

Zhuang J.¹,Wu D.-M.¹²,Xu H.¹,Huang Y.¹,Liu Y.²,Sun J.-Y.¹

Affiliation:

1. College of Mechanical and Electrical Engineering , Beijing University of Chemical Technology, Beijing , PRC

2. State Key Laboratory of Organic-Inorganic Composites , Beijing , PRC

Abstract

Abstract Hot embossing was used to fabricate a microneedle array on poly(methyl methacrylate) (PMMA) substrates. Both experimental and numerical researches were carried out to investigate the whole formation process. The results showed that the edge effect would significantly influence the replication rate of final products. An optimization design of convex flow barrier was proposed to improve the replication efficiency and structure uniformity. Furthermore, optimum parameters of the flow barrier were found to be 2 mm in length and 0.2 mm in height. Reasonable high molding temperature and force were conducive to reduce the filling time and increase the average height of microneedles.

Publisher

Walter de Gruyter GmbH

Subject

Materials Chemistry,Industrial and Manufacturing Engineering,Polymers and Plastics,General Chemical Engineering

Link

https://www.degruyter.com/document/doi/10.3139/217.3726/pdf

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