Aggregation Behavior and Thermodynamic Studies of Hydrotropes: A Review

Abstract

Abstract Under the aspect of strict environmental regulations, hydrotropy is accepted as an environmentally friendly (“green”) approach to solubilise hydrophobic compounds. Above the minimum hydrotrope concentration (MHC), hydrotropes are capable of self-aggregation; the MHC is considered the minimum requirement for solubilisation. In this article a comprehensive overview of the aggregation behaviour of different hydrotropes is presented. Details about the methods used for aggregation are given. The role of additives is discussed with respect to their influence on the MHC. Thermodynamic studies are used to evaluate the stability of a hydrotrope at different temperatures. A modern approach to the solubilization mechanism using hydrotropes is also presented in this review article. The aim of this article is to provide guidance for conducting such studies on a number of hydrotropes.