Synthesis and Antitumor and Surface Activity of Novel Tetrachloro Metallate Complexes of Sulfaquinoxaline with Co(II), Cu(II), or Sn(II) Chlorides

Abstract

AbstractNew sulfonamide tetrachloro metallate complexes that might possess strong carbonic anhydrase (CA) inhibitory properties were synthesized by the reaction of 4-amino-N-(quinoxalin-2-yl) benzene sulfonamide (sulfaquinoxaline) hydrochloride with different metal chlorides, i.e. CoCl2, CuCl2 or SnCl2. The produced metal complexes of the sulfonamide derivative, containing divalent cations, were characterized by standard procedures. These metal complexes might possess topical antiglaucoma properties which might make them more effective as pharmacological agents. The synthesized complexes exhibited significant cytotoxic activity against colon HCT-116 human cell line. Surface properties of these surfactants were investigated. The surface properties studies included critical micelle concentration (CMC), maximum surface excess (Γmax), minimum surface area (Amin). Free energy of micellization (ΔG°mic) and adsorption (ΔG°ads) were calculated.