Amoxicillin/Clavulanic Acid induced Hyperbilirubinemia in A Patient with Melanoma: A Rare Case Report

Abstract

Amoxicillin/Clavulanate is a synthetic Penicillin that is widely used today, particularly to treat respiratory and cutaneous infections. It is a generally well-tolerated oral antibiotic. However, in some cases, Amoxicillin/Clavulanate can cause side effects, primarily cutaneous, gastrointestinal, hepatic, and hematologic. Amoxicillin/Clavulanate has been linked to hundreds of cases of clinically obvious Acute Liver Injury, and this combination is now the most common cause of drug-induced liver disease in the majority of large case series. The onset of injury can range from a few days to up to 8 weeks after the start of therapy. Hyperbilirubinemia is seen in Drug-induced Cholestatic Liver Injury, but direct inhibition of transporter proteins that facilitate bilirubin transport also results in Hyperbilirubinemia. We present a case of Hyperbilirubinemia following Amoxicillin/Clavulanate administration.