Study on Drug Utilization and Evaluation of Proton Pump Inhibitors in Surgery Unit of Tertiary Care Teaching Hospital

Abstract

Proton pump inhibitors (PPIs) are one of the most commonly given prescribed drug in both outpatient and inpatient settings. Hence in this present scenario, where the use of PPIs is overwhelming, the present study aims to know the rational use of PPIs in the patients of General Surgery ward of a rural tertiary care hospital. The objective of the study is to study the drug utilization and evaluation of proton pump inhibitors in surgery unit at Adichunchanagiri Hospital and Research Center (AH&RC) BG Nagara, Mandya of tertiary care teaching hospital. A Prospective and Observational study was carried out for 6 months in the surgery department. A suitably designed patient profile form was used to record all the necessary data and the collected data is subjected to suitable statistical method for analysis. In the study, out of 200 patients on PPI, 73% were females and the rest were males. Most of the patients belonged to the age group of 36-55 years. PPIs were most frequently prescribed mainly to treat gastritis and to prevent the gastric irritation caused by analgesics. Most commonly prescribed PPIs were found to be Pantoprazole through IV route and oral route. Majority of the PPIs prescribed were appropriate based on NICE guidelines. Pantoprazole was the PPI having the greatest number of interactions with other drugs in the prescription and no ADRs were reported during our study period. PPIs should be used only when there is valid documented evidence and when their use is clinically justified. Various efforts should be made to reduce the unnecessary use of PPIs to minimize drug interactions, related risk, and the health care burden of the patients.