Investigation of Anti-anxiety Activity of Hydroalcoholic Extract of Plectranthus scutellarioides Leaves in Experimental Animal Models

Abstract

The Staircase Model (SCM) and Light and Dark Chamber (LDM) in albino rats are used in this study to investigate the possible anxiolytic-like effects of the Hydroalcoholic extract of leaves of Plectranthus scutellarioides (HEPS). The creatures were split up into four groups of six apiece. The HEPS was administered orally in 2 doses of 100 mg/kg and 200 mg/kg to control rats, while positive control animals received diazepam (2 mg/kg) treatment. One hour before the experiment, after anxiety induction, the test sample was administered orally. According to the current study, albino rats in the staircase model experience (P>0.05), considerably less climbing and rearing steps when given HEPS orally at doses of 100 mg/kg and 200 mg/kg. Additionally, in the Light and Dark Model, albino rats spend less time in the dark compared to the vehicle control, in a dose-dependent manner(P>0.05). It was discovered that the HEPS of the dose 200mg/kg body weight was quite similar to that of benzodiazepines (std drug). The HEPS was discovered to have significant anti-anxiety activity in the staircase model and the dark and light model as a result of the findings above.